Table 2.
Relationship between 6MWD and Same-visit Biomarkers
| Biomarkera | Estimate | Standard error | p-value |
|---|---|---|---|
| ET-1 (N = 55) | − 44.94 | 18.19 | 0.016 |
| NTproBNP (N = 55) | |||
| Log(NTproBNP + 1) ≤ 5.5, per 1 unit increase | − 4.67 | 7.37 | 0.53 |
| Log(NTproBNP + 1) > 5.5, per 1 unit increase | − 31.25 | 8.71 | 0.0006 |
| RDW (N = 55) | − 184.04 | 71.37 | 0.012 |
| cGMP (N = 54) | 1.78 | 10.57 | 0.87 |
| SNO-Hb (N = 50) | 1303.27 | 2822.37 | 0.64 |
| cGMP/NTproBNP ratio (N = 53) | |||
| Log(cGMP/NTproBNP + 1) ≤ 0.3, per 1 unit increase | 180.89 | 82.37 | 0.032 |
| Log(cGMP/NTproBNP + 1) > 0.3, per 1 unit increase | 27.23 | 27.30 | 0.32 |
| NO2− (N = 49) | 7.47 | 6.75 | 0.28 |
| SDMA (N = 54) | |||
| Log(SDMA + 1) ≤ 6, per 1 unit increase | 5.82 | 46.70 | 0.90 |
| Log(SDMA + 1) > 6, per 1 unit increase | − 46.96 | 25.25 | 0.067 |
| ADMA (N = 54)b | |||
| ADMA, PAH on treatment with ERA | − 0.22 | 0.087 | 0.012 |
| ADMA, PAH on treatment with PDE5i | − 0.035 | 0.11 | 0.75 |
| ADMA, PAH on treatment with ERA + PDE5i | 0.098 | 0.088 | 0.27 |
aAll biomarkers are transformed as log(biomarker + 1) with the exception of ADMA. All models were adjusted for age
bInteraction p = 0.038