Table 4.
Prediction of 6MWD Using Biomarker Value at Previous Visit in Patients with PAH
| Biomarkera | Estimate | Standard error | Standardized model coefficientsb | p-value |
|---|---|---|---|---|
| ET-1 (N = 48) | − 36.60 | 14.30 | − 15.46 | 0.015 |
| NT-proBNP (N = 49) | − 7.00 | 4.62 | − 8.63 | 0.14 |
| RDW (N = 49) | − 16.63 | 65.35 | − 1.88 | 0.80 |
| cGMP (N = 46) | − 8.51 | 12.22 | − 5.05 | 0.49 |
| SNO-Hb (N = 41) | − 5148.68 | 5365.76 | − 3.69 | 0.35 |
| cGMP/NTproBNP ratio (N = 44) | ||||
| Log(cGMP/NTproBNP + 1) ≤ 0.75c | 59.91 | 33.47 | 25.21 | 0.083 |
| Log(cGMP/NTproBNP + 1) > 0.75c | − 30.73 | 29.63 | − 12.93 | 0.31 |
| NO2− (N = 41) | 3.31 | 9.53 | 3.64 | 0.73 |
| ADMA (N = 46) | − 0.0026 | 0.064 | − 0.22 | 0.97 |
| SDMA (N = 47) | − 23.97 | 17.87 | − 7.62 | 0.19 |
aAll biomarkers were transformed as log(biomarker + 1) besides ADMA
bStandarized model coefficients quantify change per 1 standard deviation increase in values of each biomarker
cPer 1 unit increase on log scale