Table 3.
Incidence of potentially relevant 12-month follow-up re-admission
| Re-admissions, n (%)[1] | Full cohort† | Single-level only cohort‡ | ||||
|---|---|---|---|---|---|---|
| Group | P value | Group | P value | |||
| V-CBA (n = 6588) | rhBMP-2 (n = 9584) | V-CBA (n = 5683) | rhBMP-2 (n = 8505) | |||
| Patients with all-cause 12-month follow-up re-admissions [2] | 1482 (22.5) | 2021 (21.08) | – | 971 (17.1) | 1198 (14.1) | – |
| Re-admitted patients with potentially relevant procedures/diagnoses [3] | ||||||
| Subsequent lumbar fusion procedures | 623 (9.46) | 831 (8.67) | 0.0879 | 208 (3.66) | 388 (4.56) | < 0.0001* |
| Cardiac complications | 47 (0.71) | 22 (0.23) | < 0.0001^ | 25 (0.44) | 13 (0.15) | 0.0125^ |
| Deep vein thrombosis | 6 (0.09) | 3 (0.03) | 0.1725 | 4 (0.07) | 3 (0.04) | 0.7073 |
| Hematoma | 22 (0.33) | 30 (0.31) | 0.8878 | 13 (0.23) | 20 (0.23) | 0.5990 |
| Nervous system complications | 17 (0.26) | 14 (0.15) | 0.1422 | 13 (0.23) | 9 (0.11) | 0.1990 |
| Pneumonia | 80 (1.21) | 73 (0.76) | 0.0038^ | 50 (0.88) | 46 (0.54) | 0.1432 |
| Pulmonary embolism | 28 (0.43) | 37 (0.39) | 0.706 | 19 (0.33) | 22 (0.26) | 0.8748 |
| Sepsis | 2 (0.03) | 5 (0.05) | 0.7081 | 0 (0) | 1 (0.01) | 1.0000 |
| Surgical-site infection | 15 (0.23) | 20 (0.21) | 0.8634 | 8 (0.14) | 9 (0.11) | 1.0000 |
| Urinary tract infections | 144 (2.19) | 171 (1.78) | 0.0727 | 81 (1.42) | 93 (1.09) | 0.6341 |
†Planned analyses were conducted on the full cohort
‡Ad hoc analyses were conducted on the single-level only cohort, which only included patients who received treatment at a single level of the spine
*Statistically significant, Fisher’s exact test
^Statistically significant, Fisher’s exact test. Notably, differences observed in follow-up diagnoses between groups corresponded with significant comparisons in related initial Charlson comorbidities within each cohort (Table 1)
[1]All percentages were based on the total number of patients within each cohort who received V-CBA or rhBMP-2 during the initial procedure
[2]Patients with more than one re-admission were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System
[3]Except subsequent lumbar fusion procedures, repeats of the same diagnosis were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System