Fig 3.

Bioinformatic analysis identifying pathways and genes regulated by serum microRNAs that change after noncardiac surgery. (a) Signalling pathways (false-discovery rate threshold P-value<0.01), as derived from DIANA mir-Path v3.0, which bioinformatically links microRNA with their regulatory roles in biological and signalling pathways. Cardiac-specific pathways are highlighted in red. (b) Shared genes regulated by serum microRNA identified as changing after noncardiac surgery. The four microRNAs identified as changing after surgery regulate mRNA expression of SLC8A1 (NCX1, sodium–calcium exchanger) and subunits of the protein phosphatase enzyme.