Table 5.
Subgroup RCTs: influence of anaesthesia type on perioperative outcomes in total hip arthroplasty. CI, confidence interval; GA, general anaesthesia; MI, myocardial infarction; NA, neuraxial anaesthesia; OR, odds ratio; PE, pulmonary embolism. All infections, including pneumonia and sepsis; pulmonary complications, excluding pneumonia; n (NA/GA): total number of patients with NA/GA.
| Complication | NA vs GA |
NA+GA vs GA |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Studies | OR (95% CI) | n (NA) | n (GA) | P-value | Studies | OR (95% CI) | n (NA) | n (GA) | P-value | |
| Mortality | Various authors32, 34, 36 | 0.34 (0.01–8.80) | 135 | 137 | 0.519 | |||||
| Cardiac including MI | Various authors32, 34, 37 | 0.82 (0.19–3.48) | 153 | 157 | 0.783 | Dauphin and colleagues38 | 1.78 (0.15–21.51) | 20 | 17 | 0.651 |
| Cardiac excluding MI | Various authors32, 34 | 0.65 (0.08–5.38) | 87 | 91 | 0.687 | |||||
| MI | Various authors34, 37 | 0.75 (0.14–4.07) | 95 | 97 | 0.736 | Dauphin and colleagues38 | 1.78 (0.15–21.51) | 20 | 17 | 0.651 |
| Pneumonia | Various authors34, 37 | 1.03 (0.14–7.53) | 95 | 97 | 0.973 | |||||
| Acute renal failure | Liang and colleagues37 | 0.33 (0.01–8.21) | 66 | 66 | 0.498 | |||||
| Urinary retention | Various authors34, 41, 42 | 1.65 (0.89–3.05) | 158 | 162 | 0.113 | |||||
| DVT | Various authors36, 41, 50, 51 | 0.33 (0.20–0.55) | 177 | 174 | <0.0001 | Dauphin and colleagues38 | 0.81 (0.17–3.89) | 20 | 17 | 0.795 |
| PE | Various authors34, 36, 37, 41, 50, 51 | 0.40 (0.20–0.79) | 255 | 257 | 0.008 | |||||
| DVT+PE | Various authors34, 36, 37, 41, 50, 51, 55, 56 | 0.43 (0.30–0.63) | 482 | 479 | <0.0001 | Dauphin and colleagues38 | 0.81 (0.17–3.89) | 20 | 17 | 0.795 |
| CNS | Various authors34, 59 | 0.26 (0.03–2.28) | 45 | 40 | 0.222 | |||||
| All infections | Various authors34, 37 | 1.03 (0.14–7.53) | 95 | 97 | 0.973 | |||||
| Wound (superficial) | 34 | 0.33 (0.03–3.40) | 29 | 31 | 0.354 | |||||
| Blood transfusion | Various authors34, 37, 41, 61, 62, 63, 67, 68 | 0.43 (0.28–0.65) | 357 | 364 | <0.0001 | Various authors38, 61 | 0.50 (0.24–1.05) | 90 | 87 | 0.067 |
| Nerve injury | Hole and colleagues34 | 0.34 (0.01–8.80) | 29 | 31 | 0.519 | |||||
| Blood loss (ml) | Various authors36, 50, 51, 61, 62, 68, 72, 73, 74, 75, 77 | –121.82 (–152.22 to –91.42) | 334 | 335 | <0.0001 | Various authors38, 59, 61, 74, 77, 78, 79 | –20.13 (–50.10 to 9.83) | 226 | 216 | 0.188 |
| Length of stay (days) | Williams-Russo and colleagues80 | –3.00 (–6.25 to 0.25) | 44 | 46 | 0.07 | Benson and colleagues59 | –6.00 (–14.77 to 2.77) | 16 | 9 | 0.18 |
| Blood transfusion (ml) | Various authors50, 51 | –542.64 (–771.95 to –313.32) | 45 | 45 | <0.0001 | |||||