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. 2020 Nov 19;17:35. doi: 10.1186/s12977-020-00544-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Scatter plots comparing mRNA expression levels from microglia model systems. Signature comprised of 780 microglia-enriched genes are displayed as colored dots. Conserved gene expression is shown in red; genes more highly expressed in human adult microglia are shown in green, and genes more highly expressed in model systems are shown in blue (FC > 2, FDR ≤ 0.05). A panel of 15 core primary human adult microglia genes are labeled with text. a iPSC-MG vs Adult-MG, b MMG vs Adult-MG, c C20 vs Adult-MG, d HMC3 vs Adult-MG. e Stacked bar plot showing conservation and divergence of 780 primary human adult microglia enriched transcripts from putative microglia model systems. Red corresponds to conserved signatures with adult microglia (AMG), green are expressed at higher levels in AMG, blue at higher levels in the indicated model cell type