Table 1.

Overview of specific issues to be addressed in viral hepatitis theme using the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) Viral Hepatitis Theme Dataset

Virus	Example research questions to be addressed using the NIHR HIC Viral Hepatitis Theme Dataset
Hepatitis B virus (HBV) and hepatitis delta (HDV) coinfection	Characterising demographics and laboratory parameters for cases of chronic HBV infection. Improving use of biomarkers for monitoring and treatment stratification. Identifying individuals who control/clear HBV infection. Identifying subgroups that develop complications. Estimating incidence of HDV coinfection in the UK. Identifying determinants of HDV treatment success.
Hepatitis C virus (HCV)	Establishing sustained viral response rates for HCV therapy in the UK. Identifying factors determining treatment response in difficult to treat groups of patients.
Hepatitis E virus (HEV)	Estimating incidence of HEV infection in the UK. Identifying risk factors for HEV infection the UK.