Table 4.
Model 1: Results of linear mixed model for effect of dementia (CDR-SoB) measured at baseline on P-ADL level over time
| Covariates | Unadjusted models | Adjusted models | ||
|---|---|---|---|---|
| Regr. coeff. (SE) | p-value1 | Regr. coeff. (SE) | p-value1 | |
| Effect of main variable | ||||
| Time | 0.19 (0.12) | 0.109 | 0.19 (0.12) | 0.102 |
| Time*Time | 0.01 (0.01) | 0.198 | 0.01 (0.01) | 0.207 |
| Time*Time*Time | −0.0003 (0.0002) | 0.053 | −0.0003 (0.0002) | 0.054 |
| CDR-SoB BL | 0.59 (0.05) | < 0.001 | 0.57 (0.06) | < 0.001 |
| Time*CDR-SoB BL | − 0.004 (0.01) | 0.726 | − 0.003 (0.01) | 0.736 |
| Time*Time*CDR-SoB BL | −0.0006 (0.0008) | 0.438 | −0.0006 (0.0008) | 0.440 |
| Time*Time*Time* CDR-SoB BL | 0.00002 (0.00002) | 0.176 | 0.00002 (0.00002) | 0.175 |
| Effect of additional variables at baseline | ||||
| Socio –demographic information | ||||
| Age (per years) | 0.007 (0.02) | 0.771 | 0.01 (0.02) | 0.669 |
| Women | −0.53 (0.34) | 0.126 | − 0.14 (0.36) | 0.702 |
| Single | −0.81 (0.36) | 0.023 | −0.91 (0.38) | 0.016 |
| GMHR | ||||
| Poor / Fair (Good/Excellent– ref.) | 1.89 (0.33) | < 0.001 | 1.68 (0.33) | < 0.001 |
| NPI-NH | ||||
| Agitation sub-syndrome | 0.006 (0.02) | 0.812 | 0.02 (0.03) | 0.379 |
| Psychosis sub-syndrome | −0.02 (0.04) | 0.579 | − 0.03 (0.05) | 0.521 |
| Affective sub-syndrome | −0.02 (0.03) | 0.577 | −0.04 (0.03) | 0.231 |
| Apathy | 0.15 (0.06) | 0.020 | 0.14 (0.06) | 0.029 |
| Use of psychotropic medication | ||||
| Antipsychotics | −0.38 (0.50) | 0.454 | −0.10 (0.51) | 0.850 |
| Antidepressants | 0.14 (0.36) | 0.695 | 0.18 (0.37) | 0.631 |
| Anxiolytics | −0.41 (0.45) | 0.370 | −0.46 (0.46) | 0.324 |
| Hypnotics/Sedatives | 0.49 (0.39) | 0.210 | 0.50 (0.39) | 0.196 |
| Anti-dementia medication | −0.98 (0.36) | 0.007 | −0.63 (0.36) | 0.084 |
| NH Characteristics | ||||
| RU (SCU – ref.) | 1.06 (0.37) | 0.004 | 0.51 (0.39) | 0.188 |
CDR-SoB: The sum score of the domains in the Clinical Dementia Rating scale, BL: Baseline, GMHR: General Medical Health rating scale, NPI-NH: Neuropsychiatric Inventory 12-item Nursing Home version, NH: Nursing home, RU: Regular unit, SCU: Special care unit
N = 515 at T1, N = 393 at T2, N = 332 at T3, N = 271 at T4, N = 233 at T5, N = 184 at T6, N = 147 at T7
T1: baseline, T2: 6-month assessment, T3: 12-month assessment, T4: 18-month assessment, T5: 24-month assessment, T6: 30-month assessment, T7: 36-month assessment
1Bold text indicate p-value < 0.05