Table 5.
Model 2: Results of linear mixed model for effect of dementia (CDR-SoB) measured longitudinally on P-ADL level over time
| Covariates | Unadjusted models | Adjusted models | ||
|---|---|---|---|---|
| Regr. coeff. (SE) | p-value1 | Regr. coeff. (SE) | p-value1 | |
| Effect of main variable | ||||
| Time | 0.25 (0.12) | 0.038 | 0.27 (0.12) | 0.021 |
| Time*Time | 0.005 (0.009) | 0.580 | − 0.0004 (0.009) | 0.964 |
| Time*Time*Time | −0.0002 (0.0002) | 0.267 | −0.00007 (0.0002) | 0.687 |
| CDR-SoB | 0.61 (0.05) | < 0.001 | 0.55 (0.05) | < 0.001 |
| Time*CDR-SoB | −0.01 (0.01) | 0.242 | −0.01 (0.01) | 0.193 |
| Time*Time*CDR-SoB | 0.0001 (0.0008) | 0.887 | 0.0003 (0.0008) | 0.672 |
| Time*Time*Time* CDR-SoB | 0.000006 (0.00002) | 0.704 | −0.00000001 (0.00002) | 0.996 |
| Effect of additional variables at baseline | ||||
| Socio–demographic information | ||||
| Age (per years) | 0.003 (0.02) | 0.886 | 0.01 (0.02) | 0.530 |
| Women | −0.49 (0.33) | 0.143 | −0.23 (0.32) | 0.476 |
| Single | −0.65 (0.30) | 0.028 | −0.46 (0.29) | 0.116 |
| Effect of additional variables measured longitudinally | ||||
| GMHR | ||||
| Poor / Fair (Good/Excellent– ref.) | 2.04 (0.16) | < 0.001 | 1.77 (0.16) | < 0.001 |
| NPI-NH | ||||
| Agitation sub-syndrome | 0.07 (0.01) | < 0.001 | 0.04 (0.01) | 0.002 |
| Psychosis sub-syndrome | 0.07 (0.02) | 0.001 | −0.002 (0.02) | 0.915 |
| Affective sub-syndrome | 0.11 (0.02) | < 0.001 | 0.06 (0.02) | 0.001 |
| Apathy | 0.22 (0.03) | < 0.001 | 0.14 (0.03) | < 0.001 |
| Use of psychotropic medication | ||||
| Antipsychotics | 0.19 (0.26) | 0.450 | 0.08 (0.24) | 0.730 |
| Antidepressants | −0.003 (0.21) | 0.988 | − 0.17 (0.20) | 0.391 |
| Anxiolytics | 0.06 (0.22) | 0.780 | 0.03 (0.21) | 0.894 |
| Hypnotics/Sedatives | 0.42 (0.21) | 0.041 | 0.17 (0.20) | 0.382 |
| Anti-dementia medication | −1.44 (0.22) | < 0.001 | −1.17 (0.21) | < 0.001 |
| NH Characteristics | ||||
| RU (vs SCU) | 0.71 (0.24) | 0.003 | 0.59 (0.23) | 0.009 |
CDR-SoB: The sum score of the domains in the Clinical Dementia Rating scale, BL: Baseline, GMHR: General Medical Health rating scale, NPI-NH: Neuropsychiatric Inventory 12-item Nursing Home version, NH: Nursing home, RU: Regular unit, SCU: Special care unit
N = 515 at T1, N = 383 at T2, N = 320 at T3, N = 241 at T4, N = 212 at T5, N = 157 at T6, N = 121 at T7
T1: baseline, T2: 6-month assessment, T3: 12-month assessment, T4: 18-month assessment, T5: 24-month assessment, T6: 30-month assessment, T7: 36-month assessment
1Bold text indicate p-value < 0.05