Fig. 8.

TSC-Exos exert anti-apoptotic effects on tissues with Dox-induced cardiac injury. a The expression of Zeb1, Caspase3 and Bcl-2 was measured by western blotting, and β-actin was used as the reference control; the quantitative results are shown on the right. Dox indicates Dox-treated mice; Dox+Vector indicates Dox-treated mice injected with AAV9 vector; Dox+AAV indicates Dox-treated mice injected with AAV9-miR-200b inhibitor; Dox+Exo indicates Dox-treated mice injected with TSC-Exos. b The luciferase results showing miR-200b binding to Zeb1. Scramble indicates cells transfected with the scramble sequence; Mimic+WT indicates cells transfected with the miR-200b-3p and wild type 3′UTR of Zeb1; Mimic+MUT indicates cells transfected with the miR-200b-3p and mutated 3′UTR of Zeb1. #p < 0.05 compared with Dox or Scramble