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Residue-wise RMSF deviations (nm) of Mpro and RdRp with inhibitors: (A) RMSF of the protein Cα backbone atoms of Mpro_Darunavir (black); Mpro_MulberrosideE (red) (B) RMSF of the protein Cα backbone atoms ofRdRp_Remdesivir (black) and RdRp_EmblicaninA (red).