Table 2.

Univariate analysis results summary. HR: Hazard Ratio, CI: Confidence Interval.

Variable	HR (95% CI)	p-value
Age	1.023 (1.023-1.024)	< 0.001
Sex (Female vs. Male)	0.84 (0.83-0.85)	< 0.001
Race
White	1 (reference)	-
Black	0.97 (0.95-0.99)	0.006
Other	0.94 (0.90-0.97)	0.001
Hispanic origin (Yes vs. No)	0.95 (0.92-0.99)	0.028
Charlson/Deyo score
0	1 (reference)	-
1	1.22 (1.20-1.24)	< 0.001
≥ 2	1.59 (1.56-0.61)	< 0.001
Sequence number
0	1 (reference)	-
1	1 (0.98-1.01)	0.82
≥ 2	1.01 (0.92-1.11)	0.83
AJCC V8 TNM stage
IA	1 (reference)	-
IB	1.22 (1.07-1.39)	< 0.001
IIA	1.63 (1.34-1.98)	< 0.001
IIB	1.6 (1.45-1.78)	< 0.001
IIIA	2.12 (1.94-2.31)	< 0.001
IIIB	2.55 (2.32-2.81)	< 0.001
IIIC	3.26 (2.81-3.78)	< 0.001
IVA	5.25 (4.88-5.65)	< 0.001
IVB	7.04 (6.51-7.61)	< 0.001
Treatment
No surgery, no chemo, no radiation	1 (reference)	-
No surgery, no chemo, radiation done	0.72 (0.7-0.74)	< 0.001
No surgery, chemo done, no radiation	0.46 (0.45-0.47)	< 0.001
No surgery, chemo done, radiation done	0.26 (0.25-0.26)	< 0.001
Surgery done, no chemo, no radiation	0.19 (0.18-0.2)	< 0.001
Surgery done, no chemo, radiation done	0.28 (0.24-0.33)	< 0.001
Surgery done, chemo done, no radiation	0.13 (0.13-0.14)	< 0.001
Surgery done, chemo done, radiation done	0.13 (0.12-0.14)	< 0.001
Primary site
C340	1 (reference)	-
C341	0.89 (0.88-0.91)	< 0.001
C342	0.9 (0.87-0.92)	< 0.001
C343	0.96 (0.94-0.98)	< 0.001
C348	1.07 (1.03-1.11)	< 0.001
C349	1.13 (1.11-1.16)	< 0.001
Laterality
Not a paired site	1 (reference)	-
Only one side involved	0.94 (0.93-0.96)	< 0.001
Bilateral involvement	1.47 (1.4-1.54)	< 0.001
Paired site but lateral origin unknown; midline tumor	1.18 (1.15-1.21)	< 0.001
Grade
Well differentiated	1 (reference)	-
Moderately differentiated	0.99 (0.86-1.14)	0.86
Poorly differentiated	1.29 (1.15-1.46)	< 0.001
Undifferentiated	1.39 (1.23-1.56)	< 0.001
Cell type not determined, not stated or not applicable	1.44 (1.28-1.62)	< 0.001