Table 5.

Summary of total change in WMH volume and hormones levels adjusted for TIV

Total change	oCEE	tE2	Placebo	Overall	Pairwise P-value
	(n = 23)	(n = 24)	(n = 31)	P-value	oCEE / Placebo	tE2 / Placebo
WMH (cm3)	0.54 (0.60)	0.52 (0.77)	0.18 (0.28)	0.06*	0.12*	0.11*
FSH (IU/L)	−23 (21)	−33 (38)	7 (26)	<0.001	0.001	<0.001
LH (IU/L)	−6 (14)	−13 (16)	−3 (10)	0.04	0.81	0.04
E1 (pg/mL)	65 (60)	19 (22)	−4 (22)	<0.001	<0.001	0.07
E2 (pg/mL)	5 (15)	29 (39)	−10 (34)	<0.001	0.22	<0.001

Data are mean (SD)

Abbreviations; oCEE = oral conjugated equine estrogens, tE2 = transdermal estradiol, FSH = follicle stimulating hormone, LH = luteinizing hormone, E1 = estrone, E2 = estradiol, TIV = total intracranial volume, WMH = white matter hyperintensity

^*models adjusted for log-transformed TIV