Table 6.
Pearson’s partial correlations (p-values) between total change in WMH volume and total changes in hormones levels from baseline to month 48 for each treatment group. Models adjusted for the TIV.
| oCEE (n = 23) |
tE2 (n = 24) |
Placebo (n = 31) |
|
|---|---|---|---|
| FSH | 0.24 (0.28) | 0.46 (0.03) | −0.18 (0.34) |
| LH | 0.11 (0.62) | 0.10 (0.64) | −0.09 (0.64) |
| E1 | −0.43 (0.04) | −0.41 (0.054) | 0.21 (0.27) |
| E2 | −0.18 (0.43) | −0.38 (0.08) | 0.14 (0.46) |
Abbreviations; oCEE = oral conjugated equine estrogens, tE2 = transdermal estradiol, FSH = follicle stimulating hormone, LH = luteinizing hormone, E1 = estrone, E2 = estradiol, TIV = total intracranial volume