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Schematic representation of nitazoxanide antiprotease action against 3CLpro and PLpro of SARS-CoV-2. Tizoxanide (TIZ) (active metabolite of nitazoxanide) interacts with cysteine residue and thus inhibits the enzyme activity, (A) 3CLpro inhibition and (B) PLpro inhibition. Nucleophilic cysteine thiol interacts with electrophilic moieties of tizoxanide (TIZ). 3CLpro, 3-chymotrypsin like protease; PLpro, Papain like protease.
