Table 1.

Performance of the IgG, IgA and IgM assays. AUC and sensitivities (sens) are presented for different categories of infection for a low (>90 %) and high (>99 %) specificity (spec) target.

		Recent infections (<6 weeks)						Old infections (>5 months)
		Severe			Mild			Mild
Isotype	Antigen	AUC	Sens (at 90 % Spec)	Sens (at 99 % Spec)	AUC	Sens (at 90 % Spec)	Sens (at 99 % Spec)	AUC	Sens (at 90 % Spec)	Sens (at 99 % Spec)
IgG	RBD	0.94	99	91	0.93	98	98	0.94	99	96
	S1	0.90	92	84	0.92	94	93	0.93	95	47
	S1S2	0.92	92	90	0.91	92	79	0.94	99	95
	NP	0.92	95	85	0.93	98	70	0.68	95	85
	RBD + NP + S1+S1/2	0.98	99	95	0.99	99	99	0.99	99	97
	RBD + NP	0.98	99	94	0.99	99	99	0.99	99	96
IgA	RBD	0.94	97	66	0.88	84	47	0.66	42	5
	NP	0.94	97	92	0.77	62	42	0.53	15	3
	RBD + NP	0.98	97	92	0.92	84	60	0.69	42	17
IgM	RBD	0.94	100	72	0.79	68	30	0.69	65	10
	NP	0.94	97	90	0.71	53	35	0.68	46	19
	RBD + NP	0.98	100	90	0.79	68	35	0.82	65	20