. 2018 Dec 5;1(1):17–22. doi: 10.1136/bmjnph-2018-000010

Table 1.

Case reports on vitamin C deficiency and chronic alcohol intake

Reference	Country	Sex	Age	Clinical signs	Alcohol intake (drinks/day)	Plasma vitamin C (µmol/L) (RR 28–70)	Other deficiencies	Replacement regimen
Reference	Country	Sex	Age	Clinical signs	Alcohol intake (drinks/day)	Plasma vitamin C (µmol/L) (RR 28–70)	Other deficiencies	Vitamin C/day (mg)	Route	Period
Chaudhry et al ¹¹	England	Male	44	Lethargy, FH, PH, G	Chronic	<3	NS	800	Oral	2 weeks
Wang and Still¹²	USA	Male	65	E, PH, G, CH	10–15	6.82	NS	1000	NS	5 days
Wang and Still¹²	USA	Male	65	E, PH, G, CH	10–15	6.82	NS	500	NS	After 5 days
Léger¹³	Canada	Male	47	Lethargy, E, PH	8–10	<10	NS	NS	Oral	NS
Takeshima et al ¹⁴	Japan	Male	45	P, G, Oe	13	1.13	Vit B₉: 1.3 ng/mL (RR 2.4–12.0) Hb: 58 g/L (>135)	1200	Oral	3 weeks
Gião Antunes et al ¹⁵	Portugal	Male	40	GH, FH, PO	12	7.95	Vit B₉: 2.1 ng/mL (RR 2.4–12.0) Hb: 71 g/L (>135)	300	Oral	2 weeks
Gião Antunes et al ¹⁵	Portugal	Male	40	GH, FH, PO	12	7.95	Vit B₉: 2.1 ng/mL (RR 2.4–12.0) Hb: 71 g/L (>135)	100	Oral	1 month after 2 weeks
Lux-Battistelli and Battistelli¹⁶	USA	Male	54	Lethargy, weak, P, GH	Dependent	3.1	NS	1000	Oral	8–10 weeks
		Male	24	Fatigue, weak, dyspnoea, Oe	14–28	<3	NS	1000	Oral	12 weeks
		Male	48	FH, unsteady	34	<24	NS	500	Oral	12 weeks
Bennett et al ¹⁷	USA	Male	64	E, GH, unsteady weight loss	8–10	5.68	Vit B₉: 2 ng/mL (RR >4.7) Vit B₆: <2 µg/L (RR 5–50)	NS	Oral	NS

CH, corkscrew hairs;E, ecchymoses; FH, follicular hyperkeratosis; G, gingivitis; GH, gingival hypertrophy; Hb, haemoglobin; NS, not specified; Oe, oedema; P, petechiae or purpura; PH, perifollicular haemorrhages; PO, periodontitis; RR, reference range; Vit, vitamin.