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. 2020 Nov 16;12:11639–11647. doi: 10.2147/CMAR.S236188

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© 2020 Wei et al.

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IUR regulated miR-24/p53 axis to suppress the invasion and migration of UM-SCC-17A cells. Wound healing assay was used to illustrate the migration of UM-SCC-17A cells (A). Transwell assays were carried to show the invasion of cells (B). Experiments were repeated 3 times and data were expressed as mean values. The effects of IUR and miR-24 expression on the expression of p53 in UM-SCC-17A cells were analyzed by qPCR and western blot at mRNA (C) and protein (D) levels, respectively. Comparing to C and NC groups, overexpression of miR-24 led to downregulated p53 while IUR reversed the effects of overexpression of miR-24.*p < 0.05. Scale bar = 100μM.