Table 2.
SVM protein trios allowing 88.3% accuracy of correct classification of cardioembolic and atherothrombotic thrombi.
| Trio combinations | Proteins | Protein function (40) | Univariate p-value (bilateral Wilcoxon rank sum test) |
|---|---|---|---|
| 1 | • Coagulation factor XIII | Catalyzes the last step of the coagulation cascade by crosslinking fibrin fibers | 0.0022 |
| • Eukaryotic translation initiation factor 2 subunit 3 | Involved in the early steps of protein synthesis | 0.0439 | |
| • Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1. Associates with calmodulin | 0.1326 | |
| 2 | • Coagulation factor XIII | Catalyzes the last step of the coagulation cascade by crosslinking fibrin fibers | 0.0022 |
| • F-actin-capping protein | Binds to the fast-growing ends of actin filaments in a Ca2+ independent manner | 0.1752 | |
| • Myosin light chain kinase | Calcium/calmodulin-dependent kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains | 0.0142 | |
| 3 | • Coagulation factor XIII | Catalyzes the last step of the coagulation cascade by crosslinking fibrin fibers | 0.0022 |
| • Septin-7 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton | 0.1897 | |
| • Gamma-adducin | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. | 0.0589 |