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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Nat Chem Biol. 2020 Nov 16;16(12):1314–1320. doi: 10.1038/s41589-020-0644-4

Figure 1. Structure of NaVAb7.

Figure 1.

a, NaVAb structure in top view. Pore module, blue; voltage sensor, green; S4-S5 linker, red. b, NaVAb structure in side view, colored as in panel a. c, Architecture of the NaVAb pore. Glu177 side-chains (purple sticks); pore volume, grey; P loops, yellow. d, Voltage sensor. Side view illustrating the extracellular negative cluster (red, ENC), the intracellular negative cluster (red, INC), hydrophobic constriction site (purple, HCS). The Arg gating charges (R1-R4) are in blue.