Table 4.
Differential accumulation of cellular metabolites associated with central carbon metabolism.
| Metabolite | Full name | Fold change in abundancea |
|---|---|---|
| Glucose catabolism/glycolysis | ||
| Glu | Glucose | 6.64 |
| Glu6P | Glucose-6-phosphate | 8.69 |
| F6P | Fructose-6-phosphate | 6.79 |
| FBP | Fructose 1,6-bisphosphate | 0.89 |
| DHAP | Dihydroxyacetone phosphate | 1.32 |
| 3PGA | 3-phosphoglycerate | 1.43 |
| PEP | Phosphoenolpyruvate | 5.02 |
| Pentose phosphate pathway | ||
| 6PG | 6-phosphogluconate | 9.59 |
| F6P | Fructose-6-phosphate | 6.79 |
| Pyruvate metabolism | ||
| Pyruvate | Pyruvate | 1.68b |
| Acetyl-P | Acetyl-phosphate | 1.71 |
| Acetyl-CoA | Acetyl-CoA | 0.23 |
| Ethanol | Ethanol | 2.5 |
| Lactate | Lactate | 0.27 |
| Acetate | Acetate | 1.1 |
| Glutathione recycling | ||
| GSH | Glutathione (reduced) | 4.47 |
| GSSG | Glutathione (oxidized) | 1.46 |
| Leloir pathway/capsule biosynthesis | ||
| αGal1P | α-galactose-1-phosphate | 5.09 |
| UDP-Glu | UDP-glucose | 3.27 |
| UDP-Gal | UDP-galactose | 2.71 |
| UDP-GlcUA | UDP-glucuronate | 0.78 |
aFold change in total abundance comparing S. pneumoniae D39 in CDM supplemented with 30 μM Cd2+ relative to CDM alone.
bDid not meet statistical significance (P > 0.05).