Table 2.
Morphometric Assessment of White Spot Lesions and Comparisons between groups as observed and estimated using hierarchical linear modelling (HLM).
| Comparison (n = 44) | Corresponding time periods | Change in lesion size (SD) (observed values) | HLM (adjusted, estimated values) | p-Value* | |
|---|---|---|---|---|---|
| Test group | Control group | Treatment estimatea (SE) | |||
| SAP P11-4 vs placebo | Test D90–D0 vs control D90–D0 | − 0.19 (0.25) | − 0.07 (0.24) | − 0.14 (0.05) | 0.008 |
| SAP P11-4 vs FV | Test D90–D0 vs control D180–D90 | − 0.19 (0.25) | − 0.03 (0.13) | − 0.18 (0.05) | < 0.001 |
| SAP P11-4 + FV vs FV | Test D180–D0 vs control D270–D90 | − 0.20 (0.28) | − 0.04 (0.19) | − 0.17 (0.05) | 0.003 |
| FV (prior SAP P11-4) vs FV | Test D270–D90 vs control D270–D90 | − 0.06 (0.18) | − 0.04 (0.19) | − 0.02 (0.04) | 0.70 |
*p-Values indicating statistical significance are marked in bold.
aTested effect: treatment groups with HLM adjusted for gender, race, age, DMFT, WSL clinical index, oral hygiene and plaque index baseline values. Reference is control group.