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. 2020 Nov 19;10:20233. doi: 10.1038/s41598-020-75450-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hypertension increases stroke mortality and reduces spontaneous recovery. (A) Experimental design showing different time points for behavioral testing. (B) The mean arterial blood pressure of a cohort of SHR animals of the same age and weight of our stroke animals was followed for 2 weeks to establish their blood pressure (n = 6). (C) 63% of the Wistar animals achieved complete spontaneous post-stroke recovery after 24 h of MCAO, compared to 0% for SHR animals. (P < 0.0001, Fischer’s exact test) (D) & (E) Body weight was recorded for 12 weeks following MCAO comparing sham animals from both strains to stroke animals (n = 6–12 per group).