Table 3. Distribution of allele repeat numbers of the 40-bp VNTR in the DAT1 3′ UTR and 48-bp VNTR region in exon 3 of DRD4 .
Genetics findings | SCT w/o ADHD (n=31) | SCT + ADHD (n=67) | ADHD w/o SCT (n=146) | TH (n=92) | p-value | Cohen's w index | Group comparisons |
---|---|---|---|---|---|---|---|
DRD4 genotype | |||||||
At least one 7R allele | 9 (29) | 15 (22.4) | 14 (9.6) | 14 (15.2) | 0.014 | 0.178 | ADHD < SCT |
4R/4R | 15 (48.4) | 37 (55.2) | 97 (66.4) | 44 (47.8) | 0.023 | 0.168 | TD < ADHD |
DAT1 genotype | |||||||
10R homozygosity | 19 (61.3) | 35 (52.2) | 77 (52.7) | 33 (35.9) | 0.025 | 0.167 | None |
Data are presented as n (%).
ADHD = attention-deficit/hyperactivity disorder; bp = base pair; DAT1 = dopamine transporter gene; DRD4 = dopamine D4 receptor gene; SCT = sluggish cognitive tempo; TD = typically developing controls; UTR = untranslated region; VNTR = variable-number tandem repeats.