Figure 1.

Age-related expression of miRNAs indicated in silico as interacting with SIRT6 mRNA in PBMCs. (a) Levels of miR-125b-5p are not affected by age. (b) Levels of miR-34a-5p, miR-103-3p, miR-125a-5p, miR-181a-2-3p, miR-186-5p, miR-342-5p, miR-776-3p and Let-7c are significantly affected by age. Results are presented as median with interquartile range. Statistical analysis was performed with the Kruskal-Wallis test and Dunn’s multiple comparisons test. Y: young (mean age 27.5 ± 4.4 years), E: middle-aged (65.4 ± 3.3 years), LL: long-lived (93.9 ± 3.6 years)