Figure 4.

Age-related mRNA expression of proteins interacting with SIRT6 in PBMCs. Results, normalized against the expression of the β-actin gene (ACTB), are presented in arbitrary units as median mRNA levels with interquartile range. Statistical analysis was performed with the Kruskal-Wallis test and Dunn’s multiple comparisons test. (a) Direct SIRT6 interactors TP53, MYC, and MDM2. (b) Indirect SIRT6 interactors BCL2, CD48, and ICAM1. Y: young (mean age 27.5 ± 4.4 years), E: middle-aged (65.4 ± 3.3 years), LL: long-lived (93.9 ± 3.6 years)