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TAMs-CM promotes the migration and invasion of Huh-7 cells through the Gli2/IGF-II/ERK1/2 axis
(A-B) Huh-7 cells were treated with TAMs-CM, TAMs-CM and PD98059, Gli2 overexpression, or Gli2 overexpression and PD98059. Cell invasion and migration were measured by Transwell assay. (C-D) Cell migration was confirmed by scratch assay. (E) The activation of ERK1/2 and the expression of E-cadherin, vimentin and MMP-9 were analyzed by western blotting. *** p < .001, ** p < .01, * p < .05.
