Table 2. Predicted virulence-associated core, extra-cytoplasmic proteins.
| Virulence-associated GO description | Accession numbers |
|---|---|
| Aminopeptidase activity | ABA50277.1; WP_053292838.1 |
| Bacterial-type flagellum assembly | WP_004525898.1 |
| β-lactamase activity | KGV04506.1 |
| Carbohydrate metabolic processes | ABA52198.1; EDO83218.1; EEH25224.1; WP_004526045.1; WP_004526830.1; WP_004553625.1; WP_053293009.1 |
| Cell adhesion/lipid metabolic/catabolic process/chitinase | WP_004193933.1 |
| Cell adhesion/pillus | EDU07436.1; WP_004193385.1; WP_038760383.1; WP_038765499.1; WP_063597677.1 |
| Chitin catabolic process | WP_076802983.1 |
| Choline binding and transport | ABA51731.1; ABN86005.1; ABN92885.1 |
| Copper ion binding | WP_004529973.1; WP_004546221.1 |
| Heme binding | WP_004194773.1; WP_004535805.1; WP_004536717.1; WP_004538457.1; WP_004538458.1; WP_038730764.1; WP_041189005.1; WP_043304483.1; WP_076903047.1; WP_139900217.1; WP_151277731.1 |
| Heme binding/copper ion binding | WP_029671417.1; WP_122827599.1 |
| Heme binding/proteolysis | WP_009981622.1 |
| Heme bindingcopper ion binding | WP_080248664.1 |
| Hydrolase activity | CFL10512.1; EEC34719.1; WP_004525656.1; WP_024428578.1; WP_024429096.1; WP_080300428.1 |
| Lipid metabolic/catabolic process | WP_009956690.1; WP_080248725.1 |
| Metallopeptidase/metalloendopeptidase activity | AFR18870.1; WP_004548157.1; WP_011204325.1; WP_038708181.1; WP_038730428.1; WP_076887541.1 |
| N-carbamoylputrescine amidase activity | WP_045597613.1 |
| Penicillin binding/β-lactamase activity | EDO89205.1 |
| Pillus and pillus organisation | WP_151269450.1 |
| Porin activity | WP_004189892.1; WP_011205039.1 |
| Proteolysis/hydrolase activity | WP_011204795.1; WP_076852667.1 |
| Serine-type endopeptidase/carboxypeptidase activity | ABA50268.1; ACQ98979.1; AFR20596.1; WP_004528537.1; WP_004529035.1; WP_004553586.1; WP_011852052.1; WP_024428782.1; WP_038778478.1 |
| Toxin activity | WP_038707916.1 |
| Triglyceride lipase activity | EEH28759.1; WP_038741497.1; WP_038775093.1 |
| Xenobiotic transmembrane transporter activity | WP_004534049.1 |
| Putative virulence factors identified from literature and VFDB | Accession numbers |
| Acid phosphatase activity | WP_122651768.1 |
| Endoribonuclease activity | WP_004194152.1 |
| Catalytic activity | WP_065793661.1 |
| DNA-binding transcription factor activity | WP_004524330.1 |
| Methylation | AHE31311.1 |
| NAD Binding | WP_004527508.1 |
| N/A | OMW33686.1 |
| Bacterial-type flagellum assembly | WP_004198637.1 |
Analysis of the 263 putative DsbA substrates revealed 73 proteins associated with virulence, based on GO descriptions. In addition, 8 proteins were identified as potential virulence factors from literature or from database screening. Accession numbers from B. pseudomallei are shown, separated by a semicolon.