Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Mol Imaging Biol. 2020 Oct;22(5):1362–1369. doi: 10.1007/s11307-020-01514-8

Table 1.

S1PR1 radioligands with high binding potency and good selectivity

Ligands Structures IC50, nM ClogP TPSA
S1PR1 S1PR2-5
TZ4877* graphic file with name nihms-1608165-t0001.jpg 14.01 ± 0.04 > 1000 4.0 72.6
TZ4881* graphic file with name nihms-1608165-t0002.jpg 15.40 ± 3.30 > 1000 3.8 81.9
TZ35104* graphic file with name nihms-1608165-t0003.jpg 6.67 ± 0.70 > 1000 4.0 63.4
TZ43113* graphic file with name nihms-1608165-t0004.jpg 9.65 ± 1.61 > 1000 3.1 91.4
*

The binding affinity of TZ4877, TZ4881, TZ35104 and TZ43113 were reported previously [17, 18]. cLogP and TPSA: topological polar surface area were calculated by PerkinElmer ChemDraw 18.2.