Table 1.
A summary of the designed PLpro inhibitors (L1-L20).
| Sl. No. | Compd No. | R | IUPAC name | Molecular Formula |
|---|---|---|---|---|
| 1 | L1 | 4-fluorophenyl | 2-(4-fluorophenyl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C22H18FNO2 |
| 2 | L2 | 4-fluoropyridin-2-yl | 2-(4-fluoropyridin-2-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C21H17FN2O2 |
| 3 | L3 | 2-fluoropyrimidin-4-yl | 2-(2-fluoropyrimidin-4-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C20H16FN3O2 |
| 4 | L4 | 4-fluoropiperidin-3-yl | 2-(4-fluoropiperidin-3-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C21H23FN2O2 |
| 5 | L5 | 2-fluoromorpholin-3-yl | 2-(2-fluoromorpholin-3-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C20H21FN2O3 |
| 6 | L6 | 4-fluoro-1H-pyrrol-3-yl | 2-(4-fluoro-1H-pyrrol-3-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C20H17FN2O2 |
| 7 | L7 | 2-fluoro-1H-imidazol-4-yl | 2-(2-fluoro-1H-imidazol-4-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C19H16FN3O2 |
| 8 | L8 | 4-fluorofuran-3-yl | 2-(4-fluorofuran-3-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C20H16FNO3 |
| 9 | L9 | 2-fluoro-1,3-oxazol-4-yl | 2-(2-fluoro-1,3-oxazol-4-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C19H15FN2O3 |
| 10 | L10 | 5-fluoro-1,3,4-oxadiazol-2-yl | 2-(5-fluoro-1,3,4-oxadiazol-2-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C18H14FN3O3 |
| 11 | L11 | 2-fluoro-2H-pyran | 2′-fluoro-N-(naphthalen-1-yl)-3,4-dihydro-2H,2′H-[2,4′-bipyran]-4-carboxamide | C21H18FNO3 |
| 12 | L12 | 3-fluoro-1,4-dioxan-2-yl | 2-(3-fluoro-1,4-dioxan-2-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C20H20FNO4 |
| 13 | L13 | 2-fluoro-2,3-dihydro-1H-indol-6-yl | 2-(2-fluoro-2,3-dihydro-1H-indol-6-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C24H21FN2O2 |
| 14 | L14 | 4-fluoroquinolin-7-yl | 2-(4-fluoroquinolin-7-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C25H19FN2O2 |
| 15 | L15 | 4-fluoro-2H-1-benzopyran-7-yl | 2-(4-fluoro-2H-1-benzopyran-7-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C25H20FNO3 |
| 16 | L16 | 6-fluoro-9H-purin-2-yl | 2-(6-fluoro-9H-purin-2-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C21H16FN5O2 |
| 17 | L17 | 2-fluoro-1-benzofuran-5-yl | 2-(2-fluoro-1-benzofuran-5-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C24H18FNO3 |
| 18 | L18 | 2-fluoro-1H-benzimidazol-5-yl | 2-(2-fluoro-1H-benzimidazol-5-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C23H18FN3O2 |
| 19 | L19 | 2-fluoro-1,3-benzoxazol-6-yl | 2-(2-fluoro-1,3-benzoxazol-6-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C23H17FN2O3 |
| 20 | L20 | 3-fluoro-2-oxo-2H-1-benzopyran-6-yl | 2-(3-fluoro-2-oxo-2H-1-benzopyran-6-yl)-N-(naphthalen-1-yl)-3,4-dihydro-2H-pyran-4-carboxamide | C25H18FNO4 |