Table 4.
Solubility, Drug-likeness and toxicity prediction through OSIRIS Property Explorer.
| Sl.No. | Compd No. | ClogS | Drug-likeness | Mutagenic | Tumorigenic | Reproductive | Irritant |
|---|---|---|---|---|---|---|---|
| 1 | L1 | -5.633 | 1.0646 | High | High | None | None |
| 2 | L2 | -4.862 | 1.0646 | High | High | None | None |
| 3 | L3 | -4.924 | 1.0646 | High | High | None | None |
| 4 | L4 | -5.087 | 2.2466 | High | High | None | None |
| 5 | L5 | -4.629 | 2.1525 | High | High | None | None |
| 6 | L6 | -4.657 | 1.4464 | High | High | None | None |
| 7 | L7 | -4.743 | 1.5828 | High | High | None | None |
| 8 | L8 | -5.291 | 1.4464 | High | High | None | None |
| 9 | L9 | -5.377 | 1.4937 | High | High | None | None |
| 10 | L10 | -4.772 | 2.0104 | High | High | None | None |
| 11 | L11 | -5.396 | 1.6189 | High | High | None | None |
| 12 | L12 | -4.765 | -5.6984 | High | High | None | Low |
| 13 | L13 | -6.124 | 1.2642 | High | High | None | None |
| 14 | L14 | -6.339 | 1.0646 | High | High | None | None |
| 15 | L15 | -6.206 | 1.2261 | High | High | Low | None |
| 16 | L16 | -5.494 | 1.5509 | High | High | None | None |
| 17 | L17 | -7.317 | 0.9672 | High | High | None | None |
| 18 | L18 | -6.115 | 1.2445 | High | High | None | None |
| 19 | L19 | -6.749 | 1.1528 | High | High | None | None |
| 20 | L20 | -6.586 | -7.0596 | High | High | None | None |
| 21 | Control | -5.307 | 2.5325 | Low | High | None | High |