Table 1.

Characteristics of study participants (N=275)

Variable	Mean (SD) or N (percent)
Age at baseline	86.1 (5.8)
Age at death	91.3 (6.0)
Education	15.1 (2.9)
Female	199 (72.4%)
Non-Hispanic whites	267 (97.1%)
Total literacy at baseline	63.7 (13.7)
Total literacy proximate to death	57.2 (17.3)
Global cognition at baseline	0.04 (0.50)
Global cognition proximate to death	−0.68 (0.99)
MMSE at baseline	27.8 (1.9)
MMSE proximate to death	22.6 (7.9)
Alzheimer’s dementia at death	90 (33.1%)
Pathologic AD (NIA Reagan)	156 (61.9%)
Macroscopic infarcts	93 (37.2%)
Microinfarcts	94 (37.6%)
Lewy bodies	60 (23.8%)
LATE-NC
1	48 (19.3%)
2	25 (10.0%)
3	59 (23.7%)
Hippocampal sclerosis	18 (7.4%)
Cerebral amyloid angiopathy
None	61 (24.3%)
Mild	100 (39.8%)
Moderate	54 (21.5%)
Severe	36 (14.3%)
Atherosclerosis
None	78 (29.9%)
Mild	140 (53.6%)
Moderate	42 (16.1%)
Severe	1 (0.4%)
Arteriolosclerosis
None	101 (40.2%)
Mild	94 (37.5%)
Moderate	45 (17.9%)
Severe	11 (4.4%)

^*LATE-NC stage: 1=TDP-43 localized in amygdala only; 2=extension to other limbic regions; 3=extension to neocortical regions