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Stability test and reduction responsiveness study of OCholB LNPs. (A) Chemical structures of amine heads. (B) Relative hydrodynamic size variations of OCholB LNPs during storage. (C) TEM image of 77-OCholB LNPs after 10 mM DTT treatment. Scale bar = 600 nm. (D) Time-dependent relative size variations of OCholB LNPs with DTT or Cys treatments. (E) Relative size change of OCholB LNPs after 24 h of DTT or Cys incubation.
