Table 2.
Viability (mean, % (standard deviation), n = 4) of Lampsilis siliquoidea glochidia after a 48-h exposure to finasteride or melengestrol acetate (mean measured concentrationsa; mg/L). Effect data in bold are significantly different from controls
| Finasteride concentration (mg/L) | |||||||
| Control | Solvent control | 0.003 | 0.03 | 0.3 | 2.5 | 23 | |
| Finasteride | 91 (1.1) | 89 (0.7) | 90 (2.7) | 87 (2.8) | 87 (1.5) | 88 (2.4) | 85 (1.9)b |
| Melengestrol acetate concentration (mg/L) | |||||||
| Control | Solvent control | 0.005 | 0.05 | 0.3 | 1.9 | 4 | |
| Melengestrol acetate | 91 (1.1) | 89 (0.7) | 86 (0.2) | 82 (2.1)b | 85 (1.2) | 82 (3.3)b | 70 (1.4)c |
aConcentrations were measured at the beginning and end of each exposure (Table S5)
bAlthough significantly different from pooled controls, this departure represents a 5–8% decrease in survival compared with that of controls, which in light of the 10% acceptable decline in control viability (ASTM 2013), is unlikely to be biologically meaningful
cSignificant difference from pooled controls