Table 2.

Immunohistochemistry of Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), high-mobility group box 1 protein (HMGB1), and nuclear factor-κB (NF-κB)

	Control	Mild	Moderate	Severe
TLR2	1.27 ± 0.47	1.85 ± 0.55*	2.3 ± 0.48***	2.88 ± 0.35***
TLR4	1.64 ± 0.5	2.15 ± 0.55*	2.4 ± 0.52**	2.88 ± 0.35***
TLR7	1.09 ± 0.54	1.31 ± 0.48	1.5 ± 0.53	1.63 ± 0.52
TLR9	1.45 ± 0.52	1.85 ± 0.55	1.8 ± 0.79	2.38 ± 0.52**
RAGE	1.82 ± 0.6	2.08 ± 0.49	2.2 ± 0.42	2.5 ± 0.53*
HMGB1	2.09 ± 0.3	2.15 ± 0.69	2.2 ± 0.63	2.63 ± 0.52
NF-κB	2.0 ± 0.45	1.85 ± 0.36	1.8 ± 0.92	2.25 ± 0.89

^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. control