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. 2020 Nov 20;10:20297. doi: 10.1038/s41598-020-77380-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TNF-induced chromatin accessibility changes overlap with transcriptomic changes. (A) TSS plot of mFLS treated with or without 10 ng/mL TNF for 16 h showing the distribution of ATAC-seq peaks 5 kb upstream and downstream of the transcription start sites (TSS). Each dot represents one peak assigned to a unique gene. (B) TSS plot of mFLS isolated 13-week old wild-type control mouse paws and chronically inflamed paws of RA mouse showing the distribution of DNase-seq peaks 5 kb upstream and downstream of the transcription start sites (TSS). Each dot represents one peak assigned to a unique gene. (C) Venn diagram showing the overlap between differentially expressed genes and genes assigned to ATAC-seq peaks. (D) Venn diagram showing the overlap between differentially expressed genes and genes assigned to DNase-seq.