Figure 5.

SRGs regulate BMP signaling in mouse and human FLS. (A) Venn diagram showing the overlap between genes assigned to ATAC-seq and DNase-seq peaks in short-term (16 h) and chronic-TNF conditions with that of mSRGs identified from Fig. 1B. Overlapping SRGs are shown in red. (B) Venn-diagram showing the overlap between genes downregulated by > twofold in human RA-FLS treated with 10 ng/mL recombinant TNF for 8 h and 24 h with that of 34 mSAGs identified in Fig. 5A. 7 overlapping human SRGs are shown in red. (C) Heatmap of hSRGs. Each box represents one gene and is color-coded based on normalized expression levels. (D) Functional protein–protein interaction between hSRGs by STRING analysis. (E) Top 5 transcriptional factors predicted to regulate hSAGs expression identified by ChEA3 online tool.