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. 2020 Nov 20;10:20297. doi: 10.1038/s41598-020-77380-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic and chromatin accessibility profile changes at mouse and human SAGs. (A) RNA-seq, ATAC-seq and DNase-seq peak profiles in mFLS for the indicated conditions at Bmp4, Id4 and Kazald1 genomic loci. (B) RNA-seq and ATAC-seq peak profiles in hRA-FLS for the indicated conditions at BMP4, ID4 and SMAD9 genomic loci. (C) Schematic showing persistent and long-term reprogramming of signaling pathways in FLS exposed to chronic TNF exposure.