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In vitro CYP Inhibition with VZHE-039.
| Enzyme | Substrate | IC50 (μM) | |
|---|---|---|---|
| Control Inhibitor | VZHE-039 | ||
| CYP1A2 | Tacrine | α-Naphthoflavone (0.005) | 4.7 |
| CYP2C8 | Amodiaquine | Quercetin (1.2–1.75) | > 100 |
| CYP2C9 | Tolbutamide | Sulfaphenazole (0.129–0.205) | > 100 |
| CYP2C19 | S-Mephentoin | Ticlopidine (1.4) | > 100 |
| CYP2D6 | Dextromethorphan | Quinidine (0.035–0.163) | > 100 |
| CYP3A4 | Midazolam | Ketoconazole (0.018–0.0234) | > 100 |
| CYP3A4 | Testosterone | Ketoconazole (0.015–0.019) | 95.0 |
| CYP2B6 | Bupropion | Ticlopidine (0.250) | 41.4 |
