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. 2020 Nov 20;10:20295. doi: 10.1038/s41598-020-77164-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chaperone DNAJB6 blocks the seeding activities of HD patient CSF. The mHTT-ΔN17-GFP cells were transfected with DNAJB6 1 day prior to the application of mHTT51Q seeds (2 µg/ml, a) or postmortem CSF from HD, AD and PD patients (1:20, b). The assays were performed in the 384-well format. Confocal images were acquired with automation 5 days after seeding and batch analyzed to calculate Aggregation indices of the samples. Bar graphs are presented as mean ± s.e.m., n = 6–8, ***p < 0.001, N/T = non-treated controls.