Table 1.

Mutations found in clonal resistant cell lines and their sensitivity towards Hesperadin.

Genetic background	Clone	PfArk1	PF3D7_1324300	PfNek1	Hesperadin IC50 ± SEM (µM)
3D7	Parent	wt	wt	wt	0.07 ± 0.01
	2E1	wt	wt	M66I	2.07 ± 0.12
	3E6	wt	wt	M66I	2.32 + 0.24
	6G7	V59L	S2393T	wt	4.20 ± 0.01
Dd2	Parent	wt	wt	wt	0.03 ± 0.01
	8E6	wt	wt	S854Stop	2.03 ± 0.06
	1F9	wt	wt	G143D	3.55 ± 0.17
	5G8	wt	wt	A246G	4.53 ± 0.21

Data are averages of three biological experiments, each with three technical replicates, plus or minus the SEM.