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Hesperadin IC50 of PfNek1 truncations.
| Genetic background | Strain or clone | Hesperadin IC50 (µM) |
|---|---|---|
| 3D7 Nek1:HA | Drug-sensitive control | 0.005 ± 0.002 |
| 3D7 Nek1D(854-1057):HA | 1G2 | 1.9 ± 0.4 |
| 3D7 Nek1D(854-1057):HA | 2F11 | 1.8 ± 0.5 |
| Dd2 Nek1 (854 stop) | Original resistant mutant | 2.03 ± 0.06 |
Data are averages of three biological experiments, each with three technical replicates, plus or minus the SEM.
