Table 3.
The enriched pathway terms of the down regulated differentially expressed genes
| BIOCYC | |||||||
|---|---|---|---|---|---|---|---|
| Pathway ID | Pathway Name | P-value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
| 703092 | Citrulline-nitric oxide cycle | 8.83E − 02 | 2.53E − 01 | 8.24E − 01 | 1.00E + 00 | 1 | NOS2 |
| 142419 | Phospholipases | 9.82E − 02 | 2.53E − 01 | 8.24E − 01 | 1.00E + 00 | 1 | PLA2G2E, PLA2G2A |
| 545273 | Glycoaminoglycan-protein linkage region biosynthesis | 1.05E − 01 | 2.53E − 01 | 8.24E − 01 | 1.00E + 00 | 1 | B3GAT1 |
| 545323 | Urate biosynthesis/inosine 5′-phosphate degradation | 1.05E − 01 | 2.53E − 01 | 8.24E − 01 | 1.00E + 00 | 1 | NT5E |
| 142383 | Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | 1.21E − 01 | 2.53E − 01 | 8.24E − 01 | 1.00E + 00 | 1 | IDO1 |
| KEGG | |||||||
| 83051 | Cytokine-cytokine receptor interaction | 3.05E − 61 | 5.54E − 59 | 3.21E − 58 | 5.54E − 59 | 69 | IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, PDGFB, TNFSF12, IL17B, TNFRSF14, TNFRSF10C, CCL26,IL17F, TNFRSF4, IL22RA2, IL21, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, CXCL12, IL19, CCR10, XCR1, CXCL13, PPBP, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, TGFBR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, IL20, IL22,, CD40, TNFRSF13C, LTA, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, CXCR1, IL9, CXCR2 |
| 83078 | Hematopoietic cell lineage | 4.22E − 35 | 3.84E − 33 | 2.22E − 32 | 7.67E − 33 | 34 | HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, MME, KIT, CR2, TFRC, CD1A, CD3E, CSF1R, CSF2, CD8A, CD9, CSF3R, CD19, MS4A1, CD22, CD34, CD44, CD59, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7 |
| 842771 | Inflammatory bowel disease (IBD) | 4.58E − 32 | 2.78E − 30 | 1.61E − 29 | 8.34E − 30 | 28 | IL10, IL12A, IL12B, IL13, IL17A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, GATA3, IL17F, STAT6, IL21, RELA, IL23A, IFNG, IL22, RORC, IL2, IL4, IL4R, IL5, IL6 |
| 83077 | Jak-STAT signaling pathway | 4.56E − 26 | 1.19E − 24 | 6.86E − 24 | 8.30E − 24 | 33 | IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, BCL2, STAT5A, STAT6, PTPN6, IL22RA2, IL21, IL19, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF2, CSF2RB, CSF3R, IL20, IL22, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL9 |
| 213780 | Tuberculosis | 3.41E − 25 | 6.89E − 24 | 3.99E − 23 | 6.20E − 23 | 34 | IL10, IL10RA, IL12A, IL12B, CEBPB, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, BCL2, CD209, BID, FCGR2A, FCGR2B, CARD9, NOS2, CASP3, RELA, TLR9, IL23A, IFNA2, IFNB1, IFNG, TIRAP, IRAK4, CD74, MAPK11, CTSS, IL6 |
| 83120 | Asthma | 4.56E − 24 | 8.30E − 23 | 4.80E − 22 | 8.30E − 22 | 18 | IL10, IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCER1A, CCL11, CD40, IL3, IL4, IL5, IL9 |
| 125138 | Viral myocarditis | 2.26E − 16 | 2.06E − 15 | 1.19E − 14 | 4.12E − 14 | 17 | HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, BID, CASP3, CD80, CD86, CD40 |
| 373901 | HTLV-I infection | 2.85E − 15 | 2.35E − 14 | 1.36E − 13 | 5.18E − 13 | 29 | HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ETS1, STAT5A, VCAM1, RELA, RELB, LCK, SLC2A1, TGFBR1, CD3E, CSF2, EGR1, EGR2, CD40, TNFRSF13C, LTA, IL2, IL6 |
| 213306 | Measles | 4.04E − 12 | 2.53E − 11 | 1.47E − 10 | 7.35E − 10 | 19 | IL12A, IL12B, IL13, CD46, TNFRSF10C, CD209, STAT5A, FCGR2B, RELA, TLR9, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, IRAK4, IL2, IL4, IL6 |
| 83074 | Antigen processing and presentation | 7.12E − 12 | 4.32E − 11 | 2.50E − 10 | 1.30E − 09 | 15 | HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, CD8A, CD74, CTSS |
| 217173 | Influenza A | 4.98E − 11 | 2.75E − 10 | 1.59E − 09 | 9.07E − 09 | 20 | IL12A, IL12B, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1,HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF10C, RELA, IFNA2, IFNAR1, IFNB1, IFNG, IRAK4, MAPK11, IL6 |
| Pathway interaction database | |||||||
| 137933 | IL4-mediated signaling events | 7.74E − 16 | 8.36E − 14 | 4.40E − 13 | 8.36E − 14 | 17 | IL10, IL13RA1, CEBPB, AICDA, ETS1, CCL26, STAT5A, STAT6, PTPN6, PIGR, CCL11, THY1, EGR2, LTA, IL4, IL4R, IL5 |
| 137922 | IL12-mediated signaling events | 9.23E − 15 | 4.99E − 13 | 2.62E − 12 | 9.97E − 13 | 16 | IL12A, IL12B, HLA-DRA, HLA-DRB1, STAT5A, STAT6, EOMES, NOS2, RELA, RELB, LCK, IFNG, CD3E, CD8A, IL2, IL4 |
| 138000 | IL23-mediated signaling events | 1.32E − 12 | 4.75E − 11 | 2.50E − 10 | 1.42E − 10 | 12 | IL12B, IL17A, IL17F, STAT5A, NOS2, IL19, RELA, IL23A, IFNG, CD3E, IL2, IL6 |
| 137929 | IL27-mediated signaling events | 1.43E − 11 | 3.87E − 10 | 2.04E − 09 | 1.55E − 09 | 10 | IL12A, IL12B, IL17A, GATA3, STAT5A, IFNG, EBI3, IL2, IL6, IL27 |
| 138058 | BCR signaling pathway | 3.00E − 07 | 4.05E − 06 | 2.13E − 05 | 3.24E − 05 | 10 | ETS1, PTPN6, FCGR2B, BTK, POU2F2, RELA, CD19, CD22, CD79A, CD79B |
| 138055 | TCR signaling in naive CD8 + T cells | 2.28E − 04 | 1.30E − 03 | 6.82E − 03 | 2.46E − 02 | 6 | PTPN6, LCK, CD3E, CD8A, CD80, CD86 |
| 137939 | Direct p53 effectors | 2.95E − 03 | 1.33E − 02 | 7.00E − 02 | 3.18E − 01 | 8 | SPP1, BCL2, TNFRSF10C, BID, CD82, MAP4K4, CX3CL1, LIF |
| 138081 | FAS (CD95) signaling pathway | 3.67E − 03 | 1.42E − 02 | 7.46E − 02 | 3.97E − 01 | 4 | BID, BTK, CASP3, MAPK11 |
| 137995 | HIV-1 Nef: Negative effector of Fas and TNF-alpha | 3.67E − 03 | 1.42E − 02 | 7.46E − 02 | 3.97E − 01 | 4 | BCL2, BID, CASP3, RELA |
| 137944 | IL1-mediated signaling events | 2.58E − 02 | 6.45E − 02 | 3.40E − 01 | 1.00E + 00 | 3 | TOLLIP, RELA, IRAK4 |
| REACTOME | |||||||
| 1269310 | Cytokine Signaling in Immune system | 3.81E − 46 | 2.02E − 43 | 1.39E − 42 | 2.02E − 43 | 86 | IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, TRAF3, TNFRSF9, IL17A, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT, NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, IRF8, CASP3, RELA, RELB, LCK, IL23A, S1PR1, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, IL20, CD80, CD86, IL22, CD40, IRAK4, CD44, TNFRSF13C, LTA, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27, IL9 |
| 1269318 | Signaling by Interleukins | 2.98E − 33 | 7.91E − 31 | 5.42E − 30 | 1.58E − 30 | 62 | IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, IL17A, PDGFB, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT,NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, CASP3, RELA, LCK, IL23A, S1PR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, IL20, CD80, CD86, IL22, IRAK4, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R,IL7, IL27, IL9 |
| 1269203 | Innate Immune System | 4.93E − 25 | 8.72E − 23 | 5.98E − 22 | 2.62E − 22 | 82 | MASP1, TRAF3, HLA-B, PDGFB, HLA-C, MAPKAPK2, CTSC, PECAM1, MBL2, PSMB10, CD55, CD46, BCL2, DEFB103B, PTAFR, CD209, PTK2, STAT6, DEFB1, DEFB4A, CFD, PTPN6, FCAR, FCER1A, PIGR, FCGR2A, CARD9, BTK, MIF, PLA2G2A, TOLLIP, C1R, C1S, C4A, PLAU, C4BPA, CCR6, MME, C6, C7, C8A, C8B, C9, KIT, NOS2, GPI, LILRA3, VTN, CLEC6A, FN1, ATG7, ITLN1, DUSP4, ICAM2, ICAM3, RELA, RELB, TLR9, LCK, PPBP, CFI, IFNA2, LGALS3, IFNB1, CSF2, CSF2RB, CD19, SIGIRR, CD80, CD86, TIRAP, IRAK4, CD44, CD59, MAPK11, IL2, IL3, IL5, CTSS, CXCR1, MASP2, CXCR2 |
| 1269171 | Adaptive Immune System | 1.51E − 15 | 1.15E − 13 | 7.86E − 13 | 8.03E − 13 | 52 | HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, TNFRSF14, PSMB10, PTPN22, CD209, PTPN6, SLAMF6, FCGR2B, BTK, KIT, KLRB1, LILRB5, VCAM1, ICOSLG, LILRA1, LILRA3, LILRA2, ATG7, ICAM2, ICAM3, ICAM4, RELA, BTLA, LCK, CD1A, CD3E, CD8A, CD19, CD22, CD80, CD86, ICAM5, TIRAP, CD34, CD40, CD74, CD79A, CD79B, CTLA4, CTSS |
| 1269201 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 5.01E − 14 | 2.66E − 12 | 1.82E − 11 | 2.66E − 11 | 21 | HLA-B, HLA-C, SLAMF6, FCGR2B, KLRB1, LILRB5, VCAM1, LILRA1, LILRA3, LILRA2, ICAM2, ICAM3, ICAM4, CD1A, CD3E, CD8A, CD19, CD22, ICAM5, CD34, CD40 |
| 1269546 | Peptide ligand-binding receptors | 6.17E − 08 | 1.82E − 06 | 1.25E − 05 | 3.27E − 05 | 17 | CCR6, CCL13, CCR8, CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, PPBP, EDNRB, CXCR1, CXCR2 |
| 1269545 | Class A/1 (Rhodopsin-like receptors) | 4.71E − 07 | 1.14E − 05 | 7.79E − 05 | 2.50E − 04 | 21 | PTAFR, PTGER4, CCR6, CCL13,CCR8,CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, GPR183, PPBP, S1PR1, EDNRB, CXCR1, CXCR2 |
| 1269340 | Hemostasis | 1.15E − 04 | 1.47E − 03 | 1.01E − 02 | 6.09E − 02 | 26 | CD244, PDGFB, PECAM1, GATA3, PTK2, CFD, PTPN6, MIF, PLAU, NOS2, SELE, SELPLG, FN1, LCK, PPBP, IFNA2, IFNB1, CSF2, CSF2RB, CD9, CD44, CD48, CD74, IL2, IL3, IL5 |
| 1269501 | MAPK family signaling cascades | 3.27E − 04 | 3.40E − 03 | 2.33E − 02 | 1.74E − 01 | 15 | PDGFB, PSMB10, PTK2, KIT, RAG1, RAG2, FN1, DUSP4, CSF2, CSF2RB, IL2, IL3, IL5, IL6, IL6R |
| 1269240 | Toll Like Receptor TLR6:TLR2 Cascade | 3.46E − 04 | 3.40E − 03 | 2.33E − 02 | 1.84E − 01 | 8 | MAPKAPK2, BTK, DUSP4, RELA, SIGIRR, TIRAP, IRAK4, MAPK11 |
| Gen MAPP | |||||||
| MAP00400 | Phenylalanine tyrosine and tryptophan biosynthesis | 1.38E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | BID |
| MAP_kinase_activity | MAP kinase activity | 1.38E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | MAPK11 |
| MAP00010 | Glycolysis Gluconeogenesis | 2.47E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 2 | BID, GPI |
| MAP00030 | Pentose phosphate | 2.70E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | GPI |
| MAP00590 | Prostaglandin and leukotriene metabolism | 2.96E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | PLA2G2A |
| MAP00500 | Starch and sucrose metabolism | 3.34E − 01 | 5.02E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | GPI |
| MAP00330 | Arginine and proline metabolism | 5.05E − 01 | 5.81E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | NOS2 |
| MAP00380 | Tryptophan metabolism | 5.73E − 01 | 5.81E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | IDO1 |
| MAP00561 | Glycerolipid metabolism | 5.81E − 01 | 5.81E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | PLA2G2A |
| MSigDB C2 BIOCARTA (v6.0) | |||||||
| M5883 | Genes encoding secreted soluble factors | 4.86E − 27 | 7.82E − 25 | 4.43E − 24 | 7.82E − 25 | 46 | IL10, IL12A, IL12B, IL13, IL16, IL17A, PDGFB, TNFSF12, IL17B, CCL26, IL17F, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CXCL13, PPBP, IL23A, IFNA2, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, IL6, IL7, IL26, IL9 |
| M17406 | Cytokine Network | 2.71E − 22 | 2.18E − 20 | 1.24E − 19 | 4.36E − 20 | 15 | IL10, IL12A, IL12B, IL13, IL16, IL17A, IFNB1, IFNG, LTA, IL2, IL3, IL4, IL5, IL6, IL9 |
| M6910 | Cytokines and Inflammatory Response | 5.19E − 21 | 2.78E − 19 | 1.58E − 18 | 8.35E − 19 | 16 | IL10, IL12A, IL12B, IL13, HLA-DRA, HLA-DRB1, IFNB1, IFNG, CSF2, LTA, IL2, IL3, IL4, IL5, IL6, IL7 |
| M5885 | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors | 7.80E − 21 | 3.14E − 19 | 1.78E − 18 | 1.26E − 18 | 57 | IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, CTSC, IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CLEC6A, ITLN1, CXCL13, ITLN2, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2 |
| M5889 | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins | 4.62E − 17 | 1.49E − 15 | 8.43E − 15 | 7.44E − 15 | 61 | IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, SPP1, CTSC,IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7,CCL11, CCL13, CCL15,CCL16, CCL18, CCL19, CCL20,CCL22, CCL24, CXCL11,XCL1, CX3CL1, CXCL12, IL19, VTN,CLEC6A, FN1, ITLN1, CXCL13,ITLN2, PPBP, IL23A,IFNA2, LGALS3, IFNB1, IFNG, TGFBI, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2 |
| M1467 | The Co-Stimulatory Signal During T-cell Activation | 4.81E − 11 | 7.03E − 10 | 3.98E − 09 | 7.74E − 09 | 9 | HLA-DRA, HLA-DRB1, ICOSLG, LCK, CD3E, CD80, CD86, CTLA4, IL2 |
| M3952 | Cells and Molecules involved in local acute inflammatory response | 1.02E − 05 | 7.46E − 05 | 4.22E − 04 | 1.64E − 03 | 5 | C6, C7, VCAM1, SELPLG,IL6 |
| M18215 | Role of Tob in T-cell activation | 3.16E − 05 | 2.21E − 04 | 1.25E − 03 | 5.08E − 03 | 5 | IFNG, TGFBR1, CD3E, IL2, IL4 |
| M13968 | HIV-I Nef: negative effector of Fas and TNF | 6.46E − 04 | 3.15E − 03 | 1.78E − 02 | 1.04E − 01 | 6 | BCL2,PTK2, BID, CASP3, RELA, ARHGDIB |
| M13247 | T Cytotoxic Cell Surface Molecules | 1.90E − 03 | 6.80E − 03 | 3.85E − 02 | 3.06E − 01 | 3 | CD3E, CD8A, THY1 |
| Panther DB | |||||||
| P00036 | Interleukin signaling pathway | 6.51E − 19 | 2.47E − 17 | 1.05E − 16 | 2.47E − 17 | 22 | IL10,IL10RA, IL12A,IL13, IL13RA1, IL17A, MAPKAPK2, IL17F, STAT5A, STAT6, IL21, IL23A, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, CXCR1, IL9, CXCR2 |
| P00031 | Inflammation mediated by chemokine and cytokine signaling pathway | 4.36E − 07 | 8.28E − 06 | 3.50E − 05 | 1.66E − 05 | 16 | CCL26, CCL7, CCR6, CCL11, CCL13, CCR8, CCL18, CCL20, CCL22, CX3CL1, CCR10, XCR1, IFNAR1, IFNG, CXCR1, CXCR2 |
| P00053 | T cell activation | 7.23E − 05 | 8.13E − 04 | 3.44E − 03 | 2.75E − 03 | 8 | HLA-DPA1, HLA-DQA1, HLA-DRA, LCK, CD3E, CD80, CD86, CD74 |
| P00010 | B cell activation | 8.56E − 05 | 8.13E − 04 | 3.44E − 03 | 3.25E − 03 | 7 | PTPN6, BTK, CD19, CD22, CD79A, CD79B, MAPK11 |
| P00054 | Toll receptor signaling pathway | 2.14E − 03 | 1.62E − 02 | 6.86E − 02 | 8.12E − 02 | 5 | TOLLIP, RELA, TLR9, IFNB1, IRAK4 |
| P00006 | Apoptosis signaling pathway | 2.67E − 03 | 1.69E − 02 | 7.14E − 02 | 1.01E − 01 | 7 | BCL2, BID, BCL2L11, CASP3, RELA, RELB, LTA |
| P00035 | Interferon-gamma signalingpathway | 1.42E − 02 | 7.69E − 02 | 3.25E − 01 | 5.39E − 01 | 3 | PTPN6, IFNG, MAPK11 |
| P00046 | Oxidative stress response | 5.17E − 02 | 1.86E − 01 | 7.88E − 01 | 1.00E + 00 | 3 | BCL2, DUSP4, MAPK11 |
| P00047 | PDGF signaling pathway | 8.39E − 02 | 2.44E − 01 | 1.00E + 00 | 1.00E + 00 | 5 | PDGFB, MAPKAPK2, ETS1, STAT5A, STAT6 |
| P00034 | Integrin signalling pathway | 5.94E − 01 | 7.28E − 01 | 1.00E + 00 | 1.00E + 00 | 3 | ITGAE, PTK2, FN1 |
| Pathway Ontology | |||||||
| PW:0000104 | intrinsic apoptotic | 1.82E − 03 | 7.63E − 02 | 3.30E − 01 | 7.63E − 02 | 4 | BCL2, BID, BCL2L11, CASP3 |
| PW:0000515 | Interleukin-10 signaling | 7.84E − 01 | 1.57E − 01 | 6.78E − 01 | 6.78E − 01 | 1 | IL10 |
| PW:0000516 | Interleukin-6 signaling | 7.84E − 01 | 1.57E − 01 | 6.78E − 01 | 6.78E − 01 | 1 | IL6 |
| PW:0000499 | Nuclear Factor Kappa B signaling | 9.58E − 01 | 1.60E − 01 | 6.91E − 01 | 6.91E − 01 | 2 | RELA, RELB |
| PW:0000009 | programmed cell death | 1.00E + 00 | 1.80E − 01 | 7.78E − 01 | 7.78E − 01 | 2 | BCL2, CASP3 |
| PW:0000102 | The extracellular signal-regulated RAF/MEK/ERK signaling | 8.14E − 02 | 2.18E − 01 | 9.44E − 01 | 1.00E + 00 | 2 | SPP1, S1PR1 |
| PW:0000529 | angiotensin (1-7) signaling | 8.83E − 02 | 2.18E − 01 | 9.44E − 01 | 1.00E + 00 | 1 | MME |
| PW:0000106 | extrinsic apoptotic | 1.05E − 01 | 2.45E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | CASP3 |
| PW:0000559 | hexosamine biosynthetic | 1.21E − 01 | 2.55E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | GPI |
| PW:0000228 | G protein signaling via Galphai family | 1.53E − 01 | 2.80E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | S1PR1 |
| SMPDB | |||||||
| SMP00094 | Sulindac Pathway | 1.21E − 01 | 4.52E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | PLA2G2A |
| SMP00040 | Glycolysis | 2.14E − 01 | 4.52E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | GPI |
| SMP00063 | Tryptophan Metabolism | 2.70E − 01 | 4.52E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | IDO1 |
| SMP00379 | NifedipinePathway | 2.83E − 01 | 4.52E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | EDNRB |
| SMP00006 | Tyrosine Metabolism | 3.59E − 01 | 4.84E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | MIF |
| SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | 4.57E − 01 | 4.84E − 01 | 1.00E + 00 | 1.00E + 00 | 1 | MAPK11 |