Table 4.
The enriched GO terms of the up regulated differentially expressed genes
| GO ID | CATEGORY | GO Name | P Value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
|---|---|---|---|---|---|---|---|---|
| GO:0002682 | BP | Regulation of immune system process | 1.53E − 44 | 5.68E − 41 | 5.00E − 40 | 5.68E − 41 | 56 | KLRK1, ATG5, JAK1, JAK2, IFIH1, PDCD1, TRAF2, TRAF6, IKZF3, CD247, ZBTB16, ABL1, HLA-A, IKBKE, CD99, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, CCR1, IKZF1, CCL5, IRF7, CTNNB1, RUNX1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, IFNAR2 |
| GO:0009607 | BP | Response to biotic stimulus | 6.86E − 35 | 6.36E − 32 | 5.59E − 31 | 2.54E − 31 | 48 | KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF6, IKZF3, ATG10, ABL1, HLA-A, IKBKE, BST2, LILRB2, TBX21, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, IRF5, CCL5, IRF7, CCR5, GNLY, SLAMF7, IKBKB, FYN, IFI35, IL18RAP, ITGB2, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, MX1, STAT5B, CEACAM1, IFNAR2 |
| GO:0006952 | BP | Defense response | 1.12E − 33 | 5.92E − 31 | 5.21E − 30 | 4.14E − 30 | 49 | KLRK1, JAK1, JAK2, IFIH1, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, GBP1, CCRL2, SOCS1, C2, CCR1, IRF5, CCL5, IRF7, CCR5, GNLY, LTB4R, SLAMF7, IKBKB, ITGAL, FYN, IFI35, IL18RAP, ITGB2, IL18R1, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2 |
| GO:0001816 | BP | Cytokine production | 3.84E − 27 | 1.29E − 24 | 1.14E − 23 | 1.42E − 23 | 34 | KLRK1, ATG5, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, IKBKE, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, C1QBP, CLEC7A, XBP1, GBP1, SOCS1, IRF5, CCL5, IRF7, CTNNB1, RUNX1, LCP2, IL18RAP, IL18R1, CX3CR1, STAT1, NLRP3, STAT3, STAT5B, CEACAM1 |
| GO:0034097 | BP | Response to cytokine | 2.23E − 26 | 6.90E − 24 | 6.07E − 23 | 8.28E − 23 | 38 | JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, BST2, TLR2, PSMB9, XBP1, GBP1, CCRL2, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, CTNNB1, RUNX1, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, GFI1, CX3CR1, STAT1, TP53, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2 |
| GO:0042110 | BP | T cell activation | 1.68E − 25 | 4.43E − 23 | 3.90E − 22 | 6.21E − 22 | 28 | CCND3, KLRK1, ATG5, PDCD1, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, ITGAL, FYN, ITGB2, IL2RG, IL18R1, ZAP70, TP53, NLRP3, STAT3, STAT5B, CEACAM1 |
| GO:0045321 | BP | Leukocyte activation | 6.65E − 23 | 1.30E − 20 | 1.14E − 19 | 2.47E − 19 | 36 | CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1,ZAP70, CX3CR1,TP53, NLRP3, STAT3, STAT5B, CEACAM1 |
| GO:0001775 | BP | Cell activation | 2.83E − 22 | 5.00E − 20 | 4.40E − 19 | 1.05E − 18 | 37 | CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, ZAP70, CX3CR1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, GP1BB |
| GO:0080134 | BP | Regulation of response to stress | 3.88E − 18 | 3.59E − 16 | 3.16E − 15 | 1.44E − 14 | 34 | KLRK1, JAK1, JAK2, IFIH1, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, SOCS1, CCL5, IRF7, CTNNB1, IKBKB, FYN, IL18RAP, ITGB2, MAP4K2, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT5B, CEACAM1, IFNAR2 |
| GO:0051094 | BP | Positive regulation of developmental process | 1.52E − 15 | 1.00E − 13 | 8.79E − 13 | 5.64E − 12 | 31 | JAK1, JAK2, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, TLR2, C1QBP, CLEC7A, XBP1, SOCS1, CCR1, IKZF1, CCL5, CTNNB1, RUNX1, IKBKB, FYN, ITGB2, IL2RG, ZAP70, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, SMAD5, CEACAM1 |
| GO:0098552 | CC | Side of membrane | 1.17E − 11 | 1.54E − 09 | 9.47E − 09 | 3.08E − 09 | 18 | KLRK1, PDCD1, TRAF2, TRAF6, HLA-A, TLR2, LAG3, CCRL2, CCR1, CCR5, SLAMF7, IKBKB, ITGAL, FYN, ITGB2, IL2RG, KLRD1, CX3CR1 |
| GO:0043235 | CC | Receptor complex | 3.20E − 10 | 2.81E − 08 | 1.73E − 07 | 8.44E − 08 | 15 | TRAF2, TRAF6, CD247, TLR2, IKBKB, LCP2, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, KLRD1, CEACAM1 |
| GO:0009986 | CC | Cell surface | 2.20E − 09 | 9.68E − 08 | 5.96E − 07 | 5.81E − 07 | 19 | KLRK1, PDCD1, HLA-A, BST2, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, CCR1, CCR5, SLAMF7, ITGAL, ITGB2, IL2RG, KLRD1, CX3CR1, CEACAM1 |
| GO:0005887 | CC | Integral component of plasma membrane | 2.88E − 07 | 6.90E − 06 | 4.25E − 05 | 7.59E − 05 | 21 | KLRK1, TRAF2, TRAF6, CD99, LILRB2, TLR2, CCRL2, CCR1, CCR5, LTB4R, IKBKB, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, CX3CR1, CEACAM1, GP1BB, IFNAR2 |
| GO:0098805 | CC | Whole membrane | 8.24E − 06 | 1.55E − 04 | 9.56E − 04 | 2.18E − 03 | 19 | ATG5, JAK2, TRAF2, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, IRF7, LTB4R, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, ZAP70, CEACAM1 |
| GO:0044194 | CC | cytolytic granule | 1.84E − 04 | 2.70E − 03 | 1.66E − 02 | 4.87E − 02 | 2 | GZMB, GNLY |
| GO:0000790 | CC | Nuclear chromatin | 9.72E − 04 | 1.17E − 02 | 7.18E − 02 | 2.57E − 01 | 16 | IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5 |
| GO:0090575 | CC | RNA polymerase II transcription factor complex | 5.30E − 03 | 4.21E − 02 | 2.59E − 01 | 1.00E + 00 | 4 | CTNNB1, RUNX1, TP53, STAT3 |
| GO:0005667 | CC | Transcription factor complex | 5.46E − 03 | 4.21E − 02 | 2.59E − 01 | 1.00E + 00 | 6 | IKZF1, CTNNB1, RUNX1, TP53, STAT3, SMAD5 |
| GO:0048471 | CC | Perinuclear region of cytoplasm | 8.69E − 03 | 4.78E − 02 | 2.94E − 01 | 1.00E + 00 | 8 | TRAF6, ABL1, HRAS, CTNNB1, FYN, CX3CR1, STAT1, MX1 |
| GO:0019900 | MF | Kinase binding | 6.20E − 10 | 1.90E − 07 | 1.27E − 06 | 2.82E − 07 | 19 | CCND3, KLRK1, JAK2, TRAF2, TRAF6, CD247, ABL1, C1QBP, XBP1, SOCS1, CCL5, CTNNB1, IKBKB, ITGB2, MAP4K2, TP53, STAT3, CEACAM1, IFNAR2 |
| GO:0005102 | MF | Signaling receptor binding | 7.06E − 08 | 3.57E − 06 | 2.39E − 05 | 3.21E − 05 | 23 | KLRK1, JAK1, JAK2, TRAF2, TRAF6, ABL1, HLA-A, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, SOCS1, CCL5, CTNNB1, FYN, ITGB2, KLRD1, STAT1, TP53, STAT3, STAT5B |
| GO:0044212 | MF | Transcription regulatory region DNA binding | 1.45E − 07 | 5.42E − 06 | 3.63E − 05 | 6.57E − 05 | 17 | TRAF6, IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5 |
| GO:0038023 | MF | Signaling receptor activity | 3.46E − 07 | 1.13E − 05 | 7.54E − 05 | 1.58E − 04 | 21 | KLRK1, CD247, LILRB2, TLR2, LAG3, CLEC7A, CCRL2, CCR1, CCL5, CCR5, LTB4R, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, KLRD1, CX3CR1, GP1BB, IFNAR2 |
| GO:0043565 | MF | Sequence-specific double-stranded DNA binding | 5.76E − 06 | 9.35E − 05 | 6.27E − 04 | 2.62E − 03 | 16 | IKZF3, ZBTB16, ABL1, TBX21, XBP1, IRF5, IKZF1, IRF7, RUNX1, STAT1, TP53, NLRP3, STAT3, STAT4, STAT5B, SMAD5 |
| GO:0016772 | MF | Transferase activity, transferring phosphorus-containing groups | 8.11E − 06 | 1.19E − 04 | 7.98E − 04 | 3.69E − 03 | 20 | CCND3, JAK1, JAK2, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, HRAS, SOCS1, CCL5, CTNNB1, IKBKB, LCP2, FYN, ZAP70, MAP4K2, TP53, STAT3, CEACAM1 |
| GO:0070011 | MF | Peptidase activity, acting on L-amino acid peptides | 1.03E − 05 | 1.38E − 04 | 9.27E − 04 | 4.66E − 03 | 16 | ATG5, JAK2, IFIH1, TRAF2, TRAF6, BST2, GZMB, PSMB9, CLEC7A, SERPING1, C2, FYN, STAT1, TP53, NLRP3, STAT3 |
| GO:0000977 | MF | RNA polymerase II regulatory region sequence-specific DNA binding | 1.25E − 05 | 1.58E − 04 | 1.06E − 03 | 5.67E − 03 | 13 | IKZF3, ZBTB16, TBX21, XBP1, IKZF1, IRF7, RUNX1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5 |
| GO:0035639 | MF | Purine ribonucleoside triphosphate binding | 3.00E − 04 | 1.75E − 03 | 1.17E − 02 | 1.37E − 01 | 17 | JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, HRAS, CUL9, GBP1, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3, MX1 |
| GO:0032559 | MF | Adenylribonucleotide binding | 1.44E − 03 | 6.51E − 03 | 4.36E − 02 | 6.57E − 01 | 14 | JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, CUL9, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3 |
BP biological process, CC cellular component, MF molecular functions