Fig. 6.

Amlodipine alleviates cisplatin-induced renal histopathological injury in rats. A. Kidney section of control rat showing normal histological structure of glomeruli (G) and tubules (T) (H&E, X400). B. Section of amlodipine group showing high integrity of tissue with normal appearance of tubules (T) and glomeruli (G) (H&E, X400). C. Kidney section of amlodipine + cisplatin group showing congestion of the intertubular blood vessels (C), widespread vacuolar degeneration (arrow) and necrosis (dashed arrow) of the renal tubular epithelial lining (H&E, X200). D1, D2. Kidney sections of cisplatin administered rats that were treated with amlodipine showing, D1: good degree of restoration of the renal parenchyma against the action of cisplatin (H&E, X200), D2: mild degree of vacuolar degeneration (arrow) with few scattered necrotic cells and regenerated tubules (RT) (H&E, X400). E. Scoring of the main histopathological findings in various groups. One-way ANOVA followed by Tukey's post hoc test, were used for the statistical analysis of each lesion. * p < 0.05 versus control, ^#p < 0.05 versus cisplatin group.