Table 3.
Properties of venlafaxine HCl FDOF formulations.
| Formulation | Drug content (mg) ± SD | Thickness (mm) | Folding endurance | pH ± SD | Moisture content |
|---|---|---|---|---|---|
| F1 | 23.95 ± 1.63 | 0.31 | 1 | 4.26 ± 0.04 | 4.64 |
| F2 | 23.65 ± 0.83 | 0.28 | 4 | 2.9 0 ± 0.02 | 0.66 |
| F3 | 24.32 ± 1.38 | 0.35 | 1 | 4.20 ± 0.11 | 2.42 |
| F4 | 21.76 ± 0.99 | 0.24 | 1 | 3.79 ± 0.04 | 3.01 |
| F5 | 24.23 ± 1.60 | 0.30 | 12 | 3.9 0 ± 0.05 | 5.69 |
| F6 | 23.24 ± 0.59 | 0.26 | 3 | 3.79 ± 0.01 | 2.85 |
| F7 | 23.71 ± 0.56 | 0.30 | 3 | 2.99 ± 0.01 | 2.79 |
| F8 | 23.74 ± 0.16 | 0.30 | 4 | 4.23 ± 0.00 | 3.67 |
| F9 | 22.11 ± 0.50 | 0.26 | 2 | 3.85 ± 0.02 | 2.33 |
| F10 | 22.85 ± 0.27 | 0.28 | 3 | 2.92 ± 0.01 | 2.40 |
| F11 | 23.24 ± 0.68 | 0.32 | 2 | 4.17 ± 0.01 | 2.34 |
| F12 | 23.18 ± 0.44 | 0.25 | 2 | 4.17 ± 0.01 | 2.51 |
| F13 | 21.76 ± 0.99 | 0.27 | 1 | 3.79 ± 0.01 | 2.16 |
| F14 | 23.71 ± 1.69 | 0.24 | 1 | 2.98 ± 0.00 | 0.69 |
| F15 | 23.66 ± 1.13 | 0.24 | 1 | 3.83 ± 0.01 | 1.84 |
| F16 | 22.84 ± 0.59 | 0.27 | 1 | 3.76 ± 0.01 | 1.22 |
| F17 | 23.08 ± 0.38 | 0.30 | 7 | 3.88 ± 0.01 | 2.04 |
| F18 | 23.09 ± 0.64 | 0.35 | 5 | 4.23 ± 0.02 | 4.62 |
| F19 | 22.66 ± 1.54 | 0.28 | 1 | 3.81 ± 0.02 | 2.89 |
| F20 | 23.94 ± 0.24 | 0.26 | 3 | 3.06 ± 0.01 | 1.86 |
| F21 | 22.94 ± 1.59 | 0.26 | 3 | 4.28 ± 0.01 | 3.98 |
| F22 | 24.67 ± 0.30 | 0.26 | 3 | 2.93 ± 0.01 | 1.89 |
| F23 | 23.47 ± 0.76 | 0.26 | 1 | 2.9 ± 0.03 | 3.40 |
| F24 | 22.26 ± 0.61 | 0.20 | 1 | 2.96 ± 0.02 | 2.46 |
| F25 | 23.41 ± 2.41 | 0.24 | 1 | 4.16 ± 0.02 | 1.46 |
| F26 | 23.72 ± 1.23 | 0.25 | 1 | 4.19 ± 0.03 | 1.05 |
| F27 | 24.84 ± 0.43 | 0.23 | 4 | 2.96 ± 0.02 | 1.99 |