Table 3.

Determinants of RO₂:GFR in adolescents with T1D

Variables	Whole-kidney RO2:GFR (ms/mL/min)			Cortex RO2:GFR (ms/mL/min)			Medullary RO2:GFR (ms/mL/min)
	Crude values		Adjusted P valuea	Crude values		Adjusted P valuea	Crude values		Adjusted P valuea
	r	P value		r	P value		r	P value
RPF (mL/min)	−0.52	0.0009	0.004	−0.45	0.005	0.01	−0.62	<0.0001	0.003
Log UACR (mg/g)	−0.31	0.03	0.01	−0.26	0.07	0.04	0.24	0.10	0.06
MAP (mmHg)	−0.35	0.02	0.06	−0.29	0.04	0.048	−0.39	0.005	0.01
Heart rate (bpm)	0.10	0.51	0.69	0.07	0.65	0.70	0.12	0.42	0.51
Hematocrit (%)	−0.33	0.02	0.11	−0.27	0.06	0.11	−0.37	0.009	0.048
Lactate (mg/dL)	−0.34	0.02	0.004	−0.38	0.007	0.0009	−0.35	0.01	0.002
KIM-1 (pg/mL)	−0.27	0.06	0.04	−0.26	0.07	0.04	−0.26	0.07	0.047
Fat mass by DXA (kg)	−0.33	0.02	0.01	−0.29	0.049	0.02	−0.34	0.02	0.003
Waist circumference (cm)	−0.35	0.01	0.03	−0.28	0.05	0.07	−0.39	0.006	0.01
Length of diabetes (years)	−0.14	0.33	0.58	−0.19	0.19	0.33	−0.10	0.51	0.87
HbA1c (%)	0.04	0.79	0.98	−0.07	0.61	0.51	−0.04	0.77	0.54
M/I (per kg)	0.18	0.23	0.22	0.22	0.14	0.13	0.31	0.03	0.02
M/I (per FFM)	0.15	0.33	0.37	0.19	0.20	0.22	0.29	0.049	0.054
eIS	0.30	0.04	0.13b	0.27	0.07	0.09b	0.39	0.006	0.03b

^aAdjusted for age, sex, and HbA_1c.

^bAdjusted for age and sex, as HbA_1c is part of eIS equation.