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. 2020 Sep 18;69(12):2720–2734. doi: 10.2337/db19-1176

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© 2020 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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The impact of global KO of Nrf2 on survival rate and cardiac function in mice with STZ-induced diabetes. T1D in littermates of adult male WT and Nrf2KO mice on a C57BL/6J genetic background was induced by i.p. injection of STZ for 9 months (Mon) as described in research design and methods. A: Kaplan-Meier analysis of survival rate. Veh, vehicle treated. B: Representative immunoblots of myocardial Nrf2. WT, Nrf2^+/+; Nrf2KO, Nrf2^−/−. C: Cardiac function. Left panel shows a time course study of FS (%) in fold changes. Right panel shows arbitrary FS (%) and ejection fraction (EF) (%) at 9 months. #P < 0.05 between indicated groups; *P < 0.05 vs. WT STZ groups at 9 months. Animal numbers for each group (A–C) are indicated in Supplementary Fig. 1A.