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. 2020 Sep 29;69(12):2667–2677. doi: 10.2337/db20-0570

Figure 6.

Figure 6

Glucose-stimulated insulin secretion at 4 weeks (A and B) and 10 weeks (D and E) for male and female KINGS and wild-type (WT) islets. The ability of KINGS islets to respond to 20 mmol/L glucose is impaired at 10 weeks. #P < 0.05, 2 vs. 20 mmol/L; *P < 0.05, KINGS vs. age- and sex-matched WT mice; two-way ANOVA, Holm-Sidak post hoc, n = 2–6. Insulin content of islets from 4-week (C) to 10-week (F) male and female KINGS and WT mice. Insulin content is reduced in 4- and 10-week KINGS mice compared with WT. *P < 0.0001, unpaired t test, n = 9–37.