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. 2020 Nov 2;29(12):2316–2347. doi: 10.1002/pro.3979

FIGURE 4.

FIGURE 4

Proposed biosynthesis of leualacin. (a) Specialized C domains in Modules 2 and 4 catalyze ester bond formation using hydroxyacyl thioesters as acceptor substrates. Specialized A domains in the same modules activate the hydroxy acids. (b) Stand‐alone ketoreductases (KR) produce hydroxy acids from keto acids in fungal systems. Figure based on Zhang et al. 140